Analysis shows traditional Chinese medicine improves renal function in diabetic nephropathy, indicating a role for gut microbiota-derived short-chain fatty acids.
Key Points
Traditional Chinese medicine improved renal function significantly in diabetic nephropathy, reducing serum creatinine by 40%.
Increased production of short-chain fatty acids was confirmed, with fecal butyrate levels elevated by 2.5-fold after treatment.
The study utilized a streptozotocin-induced diabetic nephropathy rat model to explore the effects of traditional Chinese medicine.
Modulating the gut microbiota and its metabolites appears crucial in alleviating fibrosis, indicating a potential microbiota-targeted therapeutic strategy.