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August 8, 2025Frontiers in MedicineOpen Access

Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions

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Authors

HZHui ZhangKWKai WangHZHairui Zhao

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Overview

Current evidence highlights the pathogenesis of diabetic kidney disease and suggests that multimodal therapy improves renal protection.

Key Points

  • Improving renal protection requires addressing diabetes-related pathways involved in diabetic kidney disease.
  • Clinical trials show that therapies targeting multiple mechanisms outperform single treatments in chronic kidney disease.
  • A comprehensive approach, including lifestyle changes and pharmacologic interventions, is essential for managing diabetic kidney disease.
  • Future treatments should focus on precision medicine to effectively target inflammation and metabolic derangements.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af2b63cf1dd9ea359e4b34https://doi.org/10.3389/fmed.2025.1631053
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancements in Pharmacotherapy for Diabetic Kidney Disease: A Systematic Review2025 · 7 citations
  2. 2Diabetic Kidney Disease: From Pathophysiology to Regression of Albuminuria and Kidney Damage: Is It Possible?2025 · 5 citations
  3. 3Role of Nuclear Receptors, Lipid Metabolism, and Mitochondrial Function in the Pathogenesis of Diabetic Kidney Disease2025 · 19 citations
  4. 4Modern approaches to the management of patients with diabetic nephropathy2025
  5. 5Novel Management Approaches Diabetic Kidney Disease and Chronic Kidney Disease: A Systematic Review2025