Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study
Retrospective cohort analysis compares efficacy of polymyxins in patients with pneumonia, indicating safety concerns with nephrotoxicity.
Key Points
Colistin methanesulfonate sodium reduced 28-day mortality rates in CR-GNB pneumonia compared to other polymyxins, improving patient outcomes.
In a cohort of 331 neurocritical care patients, clinical failure rates decreased significantly with colistin methanesulfonate sodium treatment.
This retrospective cohort study analyzed efficacy and safety using original and inverse probability treatment weighting methods, highlighting treatment differences.
Despite efficacy benefits, colistin methanesulfonate sodium showed increased nephrotoxicity compared to polymyxin B and colistin sulphate, necessitating cautious use.