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August 15, 2025Infection and Drug ResistanceOpen Access

A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection

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Authors

RZRun ZhangZZZihao ZhengYLYinli Lu

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Overview

Observational study finds colistin combined with ceftazidime/avibactam improves microbiological clearance in CR-GNB infections, suggesting a new treatment approach.

Key Points

  • The colistin combined with ceftazidime/avibactam regimen achieved a microbiological clearance rate of 64.7%.
  • Patients treated with colistin and ceftazidime/avibactam had significantly better outcomes compared to other treatments, such as colistin with tigecycline.
  • The study involved a retrospective analysis of 95 patients diagnosed with carbapenem-resistant gram-negative infections.
  • While microbiological improvements were noted, no significant differences in mortality rates were observed across the treatment regimens.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c235ccb210217d64771fe1https://doi.org/10.2147/idr.s542467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparative Study of Ceftazidime–Avibactam and Meropenem-Based Regimens in the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections in Intensive Care Units2025 · 2 citations
  2. 2Impact of ceftazidime avibactam on colonization by carbapenem resistant Enterobacterales during treatment of related infections2025
  3. 3Activity of ceftazidime-avibactam combinations against carbapenem-resistant Klebsiella pneumoniae assessed by checkerboard method2025
  4. 4Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study2025
  5. 5Efficacy and Safety of Three Colistin Regimens in the Treatment of Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study2025