September 18, 2025Frontiers in ImmunologyOpen Access

From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression

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Histone lactylation significantly impacts gene expression and tumor progression, indicating its potential as a target for therapy.
Research shows that metabolic reprogramming alters the epigenetic landscape, thereby promoting immune escape and angiogenesis in tumors.
This analysis highlights the role of the tumor microenvironment in mediating histone lactylation's effects on metabolism and immunity.
Targeting histone lactylation could represent a promising strategy for enhancing cancer treatment and improving patient outcomes.

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Implication

This review explores how metabolic reprogramming connects histone lactylation and epigenetic modification, suggesting novel interventions for cancer treatment.

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Li et al. (2025) studied this question.

synapsesocial.com/papers/68d434ea713b0b5dfea745cf https://doi.org/10.3389/fimmu.2025.1542664

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Implication

This review explores how metabolic reprogramming connects histone lactylation and epigenetic modification, suggesting novel interventions for cancer treatment.

From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression

Key Points

Discussion

Implication

Cite This Study

From metabolic reprogramming to epigenetic modification: association network and targeted treatment strategy between histone lactylation and tumor progression

Key Points

Discussion

Implication

Cite This Study

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