Lactylation-mediated miRNA regulation in cancer therapy resistance

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Lactylation influences miRNA clusters, enhancing glycolytic flux in tumor cells and contributing to therapy resistance.
During stress, lactate accumulation selectively suppresses DNA-repair and pro-apoptotic miRNAs, stabilizing repair pathways.
The analysis highlights lactylation's role in immune modulation, shaping an immunosuppressive tumor microenvironment.
Future therapies may involve co-targeting lactate enzymes with oncogenic miRNAs to combat cancer resistance.

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Observational analysis reveals lactylation impacts miRNA regulation in cancer, suggesting new therapeutic strategies.

Shou et al. (2025) studied this question.

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