Microstructural geometric alterations in autism: relation with brain network and adaptive function

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This study finds reduced white matter metrics in children with autism spectrum disorder, suggesting links to brain network and cognitive function.

Children with autism spectrum disorder show significantly reduced microstructural geometric metrics, indicating underlying neural differences.
DFA metrics were significantly linked to an increased clustering coefficient and diminished adaptive function in affected children.
Director Field Analysis was employed to analyze the white matter fiber orientation in children with autism spectrum disorder.
These findings may provide insights into the neurobiological mechanisms of autism, highlighting potential biomarkers to predict adaptive function.

Wang et al. (2025) studied this question.

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This study finds reduced white matter metrics in children with autism spectrum disorder, suggesting links to brain network and cognitive function.