January 1, 2025Imaging NeuroscienceOpen Access

Widespread Associations between Behavioral Metrics and Brain Microstructure in ASD Suggest Age Mediates Subtypes of ASD

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Discussion

Analysis reveals behaviors linked to neuroimaging markers in autism spectrum disorder, suggesting age influences subtypes.

Widespread associations were identified between behavioral metrics and microstructural brain measures, indicating potential subtypes of ASD.
Analysis included 273 participants aged 8 to 17, with 148 diagnosed with ASD, revealing varied correlations across different behavioral tests.
Machine learning cluster analyses indicated that distinct neuronal profiles may exist within ASD subtypes based on behavioral assessments.
Implications suggest that understanding ASD subtypes may aid in refining treatments tailored to specific developmental trajectories.

Ressa et al. (2025) studied this question.

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