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September 15, 2025Advanced ScienceOpen Access

Phospholipid Remodeling and Tri‐Layer Membrane Reconstruction Mediate Cognitive Effects of Humanized Milk Fat Globules in Neonatal Rats

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Authors

SWShaolei WangFQFengzhi QiaoJHJianying He

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Overview

This research evaluates cognitive benefits of human milk fat globule membranes, highlighting implications for infant nutrition.

Key Points

  • Humanized milk fat globules promoted neuronal differentiation and cognitive development in neonatal rats.
  • Neonatal rats receiving humanized MFG showed increased levels of sphingomyelin and neurodevelopmental proteins.
  • Layer-by-layer methods produced stable tri-layer milk fat globules with better digestibility than single-layer variants.
  • The findings suggest that humanized MFG may be beneficial for infant formula design aimed at cognitive support.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d42047713b0b5dfea68cf8https://doi.org/10.1002/advs.202507926
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Composition, Structure, and Function of Milk Fat Globules: Thermal and Non‐Thermal Processing Effects and Their Implication in Infant Nutrition Requirements2025
  2. 2The effect of Milk Fat Globule Membrane phospholipid supplementation on cognitive function in older adults with subjective memory complaints-a randomized, double blind, placebo-controlled trial2025
  3. 3Bioengineering Human Milk Microstructure in Infant Formula: A Mini‐Review on Technological Strategies2025
  4. 4Bioactive compounds in milk/dairy foods and their value to health at key life stages: Functionality beyond nutrient supply2025
  5. 5Dietary Intake of a Milk Sphingolipid-Rich MFGM/EV Concentrate Ameliorates Age-Related Metabolic Dysfunction2025