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September 10, 2025NutrientsOpen Access

Dietary Intake of a Milk Sphingolipid-Rich MFGM/EV Concentrate Ameliorates Age-Related Metabolic Dysfunction

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Authors

RSRichard R. SprengerKKKat F. KiilerichMPMikael Palner

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Overview

Experimental analysis shows milk fat globule membranes and extracellular vesicles improve metabolic health, suggesting dietary benefits for the elderly.

Key Points

  • MFGM/EV supplementation promotes unique sphingolipid signatures in aged rats, indicating metabolic improvements.
  • The study observed a reduction in ceramide levels, which are linked to cardiovascular risks in elderly populations.
  • Enhanced lipoprotein particle turnover was linked to a general lipid-lowering effect observed in supplemented rats.
  • Whole-body lipidomic flux analysis revealed a healthier liver function associated with MFGM/EV-rich diets.

Cite This Study

Sprenger et al. (2025) studied this question.

synapsesocial.com/papers/68c23f63b210217d64796814https://doi.org/10.3390/nu17152529
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