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September 14, 2025Molecular Nutrition & Food ResearchOpen Access

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal‐Weight Rats, Prevented by Perinatal Leptin Intake

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Authors

CGCarmen García‐RuanoACAndrea CostaAPAndreu Palou

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Overview

Transcriptomic analysis reveals leptin mitigates cognitive decline in metabolically obese, normal-weight rats, suggesting early nutrition’s impact.

Key Points

  • Cognitive impairment was linked to altered hippocampal transcriptomics in metabolically obese rats.
  • The transcriptomic analysis found disrupted pathways related to obesity and cognitive decline in young metabolically obese rats.
  • Leptin supplementation during lactation prevented cognitive decline, as indicated by preserved working memory in treated rats.
  • PBMC analysis discovered overlapping genes with the hippocampus, indicating their potential as biomarkers for brain health.

Cite This Study

García‐Ruano et al. (2025) studied this question.

synapsesocial.com/papers/68d42047713b0b5dfea68b37https://doi.org/10.1002/mnfr.70262
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1When The Brain Stops Listening: Leptin Resistance As A Driver Of Hippocampal Dysfunction And Cognitive Impairment"- A Systematic Review2025
  2. 2Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism2025
  3. 3Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice2025
  4. 4High-Fat Diet Alters Behavior and Hippocampal Gene Expression2025
  5. 5Multi-Omics Analyses Unveil the Effects of a Long-Term High-Salt, High-Fat, and High-Fructose Diet on Rats2026