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September 10, 2025Journal of Neonatal SurgeryOpen Access

When The Brain Stops Listening: Leptin Resistance As A Driver Of Hippocampal Dysfunction And Cognitive Impairment"- A Systematic Review

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Authors

AMArijit Mazumdar

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Overview

This systematic review explores how leptin resistance affects cognitive decline in obesity, indicating potential therapeutic strategies.

Key Points

  • Leptin resistance disrupts cognitive function linked to hippocampal impairments, particularly affecting memory.
  • Emerging evidence shows that high-fat diets are significant contributors to leptin resistance and cognitive decline.
  • Therapeutic interventions targeting leptin signaling may alleviate cognitive impairments, enhancing hippocampal function.
  • Lifestyle modifications like caloric restriction can improve leptin sensitivity and promote cognitive health.

Cite This Study

Arijit Mazumdar (2025) studied this question.

synapsesocial.com/papers/68c2427db210217d647a35bahttps://doi.org/10.63682/jns.v14i8.8368
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Leptin and Leptin Resistance in Obesity: Current Evidence, Mechanisms and Future Directions2025
  2. 2Therapeutic Potential of Leptin in Neurodegenerative Disease2025
  3. 3Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal‐Weight Rats, Prevented by Perinatal Leptin Intake2025
  4. 4Leptin Signaling in the Hypothalamus: Cellular Insights and Therapeutic Perspectives in Obesity2025
  5. 5The Mystery Hormone: Leptins Uncetain Role in the Body as a Hormone2025