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September 12, 2025Journal of Agricultural and Food Chemistry

Chitosan Oligosaccharide Attenuates Neuroinflammation by Regulating Microglial Immunometabolic Reprogramming via the mTOR Signaling Pathway

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Authors

HCHongli ChenMCMingyang CaiYHYue He

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Overview

Experimental analysis shows chitosan oligosaccharide influences microglial immunometabolic processes in LPS-challenged mice, suggesting it may enhance cognitive performance.

Key Points

  • Chitosan oligosaccharide effectively normalized microglial immunometabolism, improving cognitive performance in mice.
  • Mice treated with chitosan oligosaccharide showed reduced mTOR activation and neuronal damage after LPS exposure.
  • Enhancements in oxidative phosphorylation were observed due to chitosan oligosaccharide's regulatory effects on microglial metabolism.
  • This research highlights chitosan oligosaccharide as a potential therapeutic for neuroinflammation-related disorders.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea67ab2https://doi.org/10.1021/acs.jafc.5c05010
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Also Consider

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  1. 1Immunomodulatory effects of chitosan oligosaccharides produced by chitosanase from Bacillus isolate2025
  2. 2N-Acetylchitooligosaccharides Alleviate Pulmonary Inflammation and Modulate Glycerophospholipid Metabolism in Murine Acute Lung Injury2025
  3. 3Sulfated Fucooligosaccharides Ameliorated Neuroinflammation in <scp>D</scp>-Galactose-Induced Aging Model Mice via the Gut–Brain Axis2025
  4. 4Investigation of the Mitigating Effect of Chitosan Oligosaccharides on Cow’s Milk Allergy2025
  5. 5Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease2025 · 30 citations