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September 18, 2025International Journal of Molecular SciencesOpen Access

N-Acetylchitooligosaccharides Alleviate Pulmonary Inflammation and Modulate Glycerophospholipid Metabolism in Murine Acute Lung Injury

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Authors

XSXiongjie SunFLFanlu LiuBHBaifei Hu

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Overview

This study demonstrates NACOS' effects on pulmonary inflammation and glycerophospholipid metabolism in mice, suggesting therapeutic potential.

Key Points

  • N-acetylchitooligosaccharides significantly reduce pulmonary inflammation in murine models of acute lung injury.
  • Histopathological analysis revealed reduced edema and preservation of tight junctions in treated mice.
  • Metabolomic analysis identified glycerophospholipid metabolism as significantly altered following NACOS treatment.
  • Findings indicate a dual mechanism of action involving inflammatory mediator suppression and metabolic modulation.

Cite This Study

Sun et al. (2025) studied this question.

synapsesocial.com/papers/68d435d6713b0b5dfea751echttps://doi.org/10.3390/ijms26189128
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