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October 15, 2025AMB ExpressOpen Access

Immunomodulatory effects of chitosan oligosaccharides produced by chitosanase from Bacillus isolate

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Authors

ASAkram N. SalahNENooran S. ElleboudyMFMohamed M. S. Farag

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Overview

This research assesses the immunostimulatory and anti-inflammatory effects of chitosan oligosaccharides, indicating their potential as therapeutic agents.

Key Points

  • Chitosan oligosaccharides enhanced cytokine levels in the thymus and spleen, indicating immunostimulatory effects.
  • Cytokines IL-6, TNF-α, and IFN-γ were significantly increased (p < 0.05) after treatment with chitosan oligosaccharides.
  • Oral administration of chitosan oligosaccharides showed significant anti-inflammatory potential compared to dexamethasone (p < 0.05).
  • Purification of chitosan oligosaccharides was achieved through Sephadex LH-20 column chromatography, followed by UPLC-Mass spectroscopy analysis.

Cite This Study

Salah et al. (2025) studied this question.

synapsesocial.com/papers/68efa18f9d05deea71d13dd5https://doi.org/10.1186/s13568-025-01958-7
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Also Consider

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  5. 5Advances in Chitosanase Research: From Structure and Function to Green Biocatalytic Production of Chitooligosaccharides2025