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August 19, 2025ACS Nano

Mucoadhesive and Self-Assembled Chitosan Oligosaccharide-Glycyrrhizin Nanoparticle for Oral Nanotherapeutic in Inflammatory Bowel Disease

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Authors

GLGayoung LimHKHa Rin KimCYChaerim Yoo

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Overview

Nanoparticle therapy mitigates inflammation in inflammatory bowel disease, suggesting new treatment options.

Key Points

  • COS-GL nanoparticles significantly reduce inflammation and promote mucosal healing in a colitis mouse model, showing promise for IBD treatment.
  • In vitro studies indicate these nanoparticles effectively suppress pro-inflammatory cytokines and neutralize reactive oxygen species.
  • The mucoadhesive properties of chitosan oligosaccharide improve retention at inflamed intestinal tissues, enhancing therapeutic effects.
  • COS-GL nanoparticles outperform both their individual components and standard therapeutic options for IBD.

Cite This Study

Lim et al. (2025) studied this question.

synapsesocial.com/papers/68af33ddcf1dd9ea359e8aabhttps://doi.org/10.1021/acsnano.5c09985
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