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September 10, 2025Journal of Agricultural and Food Chemistry

Sulfated Fucooligosaccharides Ameliorated Neuroinflammation in D-Galactose-Induced Aging Model Mice via the Gut–Brain Axis

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Authors

MXMeilan XueXZXuehan ZhangYZYifan Zhou

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Overview

Treatment with sulfated fucooligosaccharides improved cognitive dysfunction and reduced neuroinflammation in aging mice, suggesting a role for the gut-brain axis.

Key Points

  • FOS treatment ameliorated neuroinflammation and improved memory and cognitive functions in aging mice.
  • FOS reduced microglia activation by lowering the expression of key inflammatory markers such as COX-2 and NF-κB.
  • Fecal microbiota transplantation from treated mice mirrored the neuroprotective effects of FOS, indicating the role of gut microbiota.
  • FOS supplementation also enhanced gut health by increasing butyric acid levels and enriching gut flora diversity.

Cite This Study

Xue et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64784e87https://doi.org/10.1021/acs.jafc.5c08350
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