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September 12, 2025Open Access

High-Resolution Genomic and Molecular Characterization of Vancomycin-Resistant Enterococci from Hospitalized Patients in a Tertiary Care Center in Riyadh, Saudi Arabia

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Authors

LALatifah D. AlmasaudMAManal M. AlkhulaifiAGAkela Ghazawi

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Overview

Investigative analysis reveals antimicrobial resistance and genetic diversity in vancomycin-resistant enterococci, highlighting critical factors for infection control.

Key Points

  • VRE isolates display high resistance rates, particularly in Enterococcus faecium, with 100% resistant to vancomycin.
  • Whole genome sequencing revealed complex resistome and virulome profiles, with multiple sequence types identified.
  • Analysis identified diverse plasmid replicons co-associated with antimicrobial resistance genes among Enterococcus faecium isolates.
  • Urgent need for genomic surveillance is highlighted to improve infection control and manage antibiotic resistance.

Cite This Study

Almasaud et al. (2025) studied this question.

synapsesocial.com/papers/68d41da8713b0b5dfea66f9ahttps://doi.org/10.21203/rs.3.rs-7451957/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Critical genomic insights into vancomycin-resistant <i>Enterococcus faecium</i> in Lebanon2025
  2. 2Surveillance and Characterization of Vancomycin-Resistant and Vancomycin-Variable Enterococci in a Hospital Setting2025
  3. 3Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium Isolates with Full and Truncated vanA Operons from Russian Hospitals2025
  4. 4Molecular characterization of vancomycin-resistant Enterococcus faecium and identification of a clinical strain co-harboring the G2505A mutation associated with linezolid resistance from a tertiary hospital in China2026
  5. 5Virulence signature of the endemic vancomycin-resistant <i>Enterococcus faecium</i> clones in Denmark, 2015-20232025