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August 25, 2025AntibioticsOpen Access

Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium Isolates with Full and Truncated vanA Operons from Russian Hospitals

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Authors

ASAnna A. SlavokhotovaASAndrey ShelenkovYMYulia Mikhaylova

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Overview

Genomic investigation reveals vanA operon variants in vancomycin-resistant Enterococcus faecium isolates, highlighting antimicrobial resistance trends.

Key Points

  • All isolates belonged to the CC17 lineage, underscoring their clinical significance as hospital pathogens.
  • Whole genome sequencing confirmed two isolates with truncated vanA operon, pointing to emerging resistance variants.
  • Phylogenetic analysis showed local clonal expansion of VREfm strains, indicating potential international connections.
  • Genomic monitoring underscores the need for better understanding of antimicrobial resistance evolution in enterococci.

Cite This Study

Slavokhotova et al. (2025) studied this question.

synapsesocial.com/papers/68af7c997567bf4f94ff4504https://doi.org/10.3390/antibiotics14090858
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