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August 27, 2026Microbiology SpectrumOpen Access

Molecular characterization of vancomycin-resistant Enterococcus faecium and identification of a clinical strain co-harboring the G2505A mutation associated with linezolid resistance from a tertiary hospital in China

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Authors

NSNi SuoYWYujing WangCCChunguang Chen

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Overview

Genomic analysis reveals dual vancomycin resistance clusters and linezolid-resistant mutations in clinical Enterococcus faecium, highlighting threats of multidrug-resistant nosocomial spread.

Key Points

  • To characterize the molecular epidemiology and resistance mechanisms of clinical vancomycin-resistant Enterococcus faecium isolates from a tertiary hospital in China.
  • Identified and analyzed 18 clinical vancomycin-resistant Enterococcus faecium isolates using MALDI-TOF mass spectrometry and whole-genome sequencing.
  • Conducted antimicrobial susceptibility testing via broth microdilution and assessed plasmid-mediated resistance transfer using conjugation assays.
  • Among 18 isolates, 13 carried only the vanHAX gene cluster while 5 harbored both vanHAX and vanHMX gene clusters, with ST80 being the predominant sequence type (44.4%, 8/18).
  • Identified a sequentially isolated strain from a single patient that gained a G2505A mutation in the 23S rRNA gene conferring linezolid resistance alongside dual vancomycin resistance clusters.

Cite This Study

Suo et al. (2026) studied this question.

synapsesocial.com/papers/6a8fe9b910c91c1e92621a22https://doi.org/10.1128/spectrum.00014-26
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