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September 10, 2025Microbiology SpectrumOpen Access

Virulence signature of the endemic vancomycin-resistant Enterococcus faecium clones in Denmark, 2015-2023

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Authors

IRIngrid Maria Cecilia RubinKKKasper Thystrup KarstensenMLMikkel Lindegaard

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Overview

Observational analysis identified new virulence markers in Enterococcus faecium, suggesting implications for public health tracking and outbreak response.

Key Points

  • Identified eight new putative virulence genes, increasing the total to 35, which may enhance pathogenicity.
  • Significant differences in virulence markers observed across six dominant VREfm clusters during the study period.
  • Assessment utilized whole-genome sequencing and single linkage clustering to analyze bloodstream isolates.
  • New virulence database provides essential tools for outbreak investigations and surveillance in healthcare settings.

Cite This Study

Rubin et al. (2025) studied this question.

synapsesocial.com/papers/68c23ed7b210217d64793bf9https://doi.org/10.1128/spectrum.01289-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Surveillance and Characterization of Vancomycin-Resistant and Vancomycin-Variable Enterococci in a Hospital Setting2025
  2. 2Molecular characterization of vancomycin-resistant Enterococcus faecium and identification of a clinical strain co-harboring the G2505A mutation associated with linezolid resistance from a tertiary hospital in China2026
  3. 3Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium Isolates with Full and Truncated vanA Operons from Russian Hospitals2025
  4. 4Deciphering vancomycin resistance in Enterococcus faecium: gene distribution, sequence typing, and global phylogenetic analysis2025
  5. 5Comparative core-genome MLST of vancomycin-resistant Enterococcus faecium supports the utility of wastewater-based surveillance: a pilot study2026