Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Clinical Laboratory

Role of NR1D1 in Colorectal Cancer: Impact on Prognosis, Immune Microenvironment, and Oncogenic Pathways

View Full Paper
Ask AI
Bookmark
Share

Authors

XZXingshu ZhuMWMing WangDDDeren Du

Discussion

Loading...

Member takes

Overview

Analysis reveals NR1D1 expression influences prognosis in colorectal cancer, indicating its role in oncogenic pathways and immune microenvironment.

Key Points

  • High NR1D1 expression correlates with poor prognosis in colorectal cancer patients.
  • Multivariate Cox regression identified NR1D1 as an independent prognostic factor alongside age and stage.
  • Bioinformatics analysis utilized transcriptomic data to evaluate NR1D1 levels across clinical stages of colorectal cancer.
  • Increased immune infiltration was observed in the low NR1D1 expression group, pointing to its potential influence on the immune microenvironment.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea619a9https://doi.org/10.7754/clin.lab.2025.250221
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer2025 · 3 citations
  2. 2Expression of the High Affinity Neurotensin Receptor Defines an Immune‑cold, Poor‑prognosis Colorectal Cancer Subtype2026
  3. 3Transformative insights from transcriptome analysis of colorectal cancer patient tissues: identification of four key prognostic genes2025
  4. 4Exploring the prognostic value and immune landscape of EGLN1 in colorectal cancer: insights from bioinformatics analysis2025
  5. 5Define a good prognosis of RNF43 codon 659-mutated and concomitant genomic signatures in CRC: an analysis of the cBioPortal database2025