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August 20, 2025PeerJOpen Access

Transformative insights from transcriptome analysis of colorectal cancer patient tissues: identification of four key prognostic genes

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Authors

NBNevin BelderSCSulgun CharyyevaEOErtan Oruç

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Overview

Transcriptome analysis reveals four prognostic genes in colorectal cancer, suggesting new strategies for survival prediction.

Key Points

  • The developed prognostic risk score predicts lower overall survival in high-risk colorectal cancer patients, pinpointing the importance of identified genes.
  • Key evidence includes a multivariate Cox regression analysis which showed significantly poorer overall survival in high-risk patients based on four overexpressed genes.
  • Assessment using transcriptome profiling on 49 matched tumor and normal samples unveiled 845 differentially expressed genes in colorectal cancer.
  • This analysis emphasizes the potential for personalized management strategies and highlights the need for further studies on prognostic gene importance.

Cite This Study

Belder et al. (2025) studied this question.

synapsesocial.com/papers/68af4088cf1dd9ea359ec01ehttps://doi.org/10.7717/peerj.19852
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