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August 8, 2025Frontiers in OncologyOpen Access

Define a good prognosis of RNF43 codon 659-mutated and concomitant genomic signatures in CRC: an analysis of the cBioPortal database

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Authors

FWFeng WangLLLiang‐In LinZLZhongkang Li

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Overview

Analysis of RNF43 mutations and genomic signatures reveals varied prognoses in colorectal cancer, suggesting tailored therapies.

Key Points

  • Patients with RNF43 codon 659 mutations and MSI-H had the best overall survival outcomes, indicating significant prognostic value.
  • The study analyzed data from 4028 CRC patients, finding the most common mutation was in codon 659 of RNF43 with frameshift variants.
  • Methods included Cox regression analysis to evaluate the impact of key biomarkers like MSI-H and BRAF on survival outcomes.
  • Findings call for targeted approaches in clinical management for patients with specific mutations in colorectal cancer.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68af2b56cf1dd9ea359e421ahttps://doi.org/10.3389/fonc.2025.1608664
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