Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Frontiers in ImmunologyOpen Access

Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

LTLulu TanSWShuaifeng WangWCWeilong Chang

Discussion

Loading...

Member takes

Overview

Develops a novel necroptosis-related gene signature predicting outcomes in colorectal cancer patients, suggesting implications in immune activity.

Key Points

  • The novel signature of eighteen necroptosis-related genes effectively predicts the prognosis of colorectal cancer patients.
  • Performance was validated across three independent cohorts, ensuring its robustness in predicting outcomes related to colorectal cancer.
  • Bioinformatics analyses revealed significant links between necroptosis and immune activity in the tumor microenvironment.
  • Differences in drug sensitivity were observed based on necroptosis-related gene expression among the two-risk groups.

Cite This Study

Tan et al. (2025) studied this question.

synapsesocial.com/papers/68c239a3b210217d6477c839https://doi.org/10.3389/fimmu.2025.1619749
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Construction and validation of a necroptosis-related lncRNA signature for predicting the prognosis of gastrointestinal cancer patients.2025
  2. 2Prognostic Implications and Immune Landscape Analysis of Necroptosis-associated Gene Signatures in Acute Myeloid Leukemia2025 · 3 citations
  3. 3Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration.2025
  4. 4A Notch signal pathway related gene signature predicts overall survival in colorectal cancer2025
  5. 5Machine Learning-Derived Neddylation Gene Signature for Predicting Prognosis and Immunotherapy Benefits in Colorectal Cancer2025 · 1 citations