Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 11, 2025Protein & CellOpen Access

Systematic analyses uncover plasma proteins linked to incident cardiovascular diseases

View Full Paper
Ask AI
Bookmark
Share

Authors

YCYi-Lin ChenJWJijing WangJYJia You

Discussion

Loading...

Member takes

Overview

Comprehensive analyses reveal plasma proteins are linked to cardiovascular disease risks, suggesting potential for drug repurposing.

Key Points

  • Significant associations were identified between plasma proteins and cardiovascular disease outcomes, highlighting their potential role in diagnostics.
  • Among 892 unique proteins, NT-proBNP and GDF15 showed strong associations with heart failure and atrial fibrillation, respectively.
  • Two-sample Mendelian randomization analysis linked 225 proteins to cardiovascular disease risk, indicating drug repurposing possibilities.
  • Insights into how risk factors mediate protein-CVD relationships were uncovered, pointing to a multifactorial approach in cardiovascular health.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d413ee713b0b5dfea6180fhttps://doi.org/10.1093/procel/pwaf072
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood plasma proteome-wide association study implicates novel proteins in the pathogenesis of multiple cardiovascular diseases2025
  2. 2Plasma Proteomics Linking Primary and Secondary diseases: Insights into Molecular Mediation from UK Biobank Data2025
  3. 3Circulating Cardiovascular Proteomic Associations With Genetics and Disease2025
  4. 4Blood pressure, plasma proteins, and cardiovascular diseases: a network Mendelian randomization and observational study2025
  5. 5Proteomic analysis identifies lipoprotein(a)-associated proteins linked to incident atherosclerotic cardiovascular disease events2025