Mendelian randomization reveals 242 proteins influencing blood pressure in relation to cardiovascular diseases, suggesting significant mediation effects.
Key Points
A total of 242 proteins significantly associated with blood pressure were identified, providing insights into potential mediators in cardiovascular diseases.
Observational analysis showed that 30.5% to 77.2% of the relationship between proteins and cardiovascular diseases was explained through blood pressure regulation.
Key proteins, including FURIN and FGF5, exhibited strong associations with both blood pressure and stroke risk, underscoring their potential causal roles.
Network Mendelian randomization highlighted the important relationship between blood pressure and cardiovascular diseases, identifying promising protein targets for further research.