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October 8, 2025Circulation Genomic and Precision MedicineOpen Access

Circulating Cardiovascular Proteomic Associations With Genetics and Disease

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Authors

KMKathryn A. McGurkLCLara CurranASArunashis Sau

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Overview

Observational study reveals links between circulating proteins and genetic variants in cardiovascular disease, suggesting ACE2 may reduce hypertension risk.

Key Points

  • Identifying variances in circulating proteins helps understand factors influencing cardiovascular disease.
  • Significant biomarkers like ACE2 are found to play protective roles against hypertension and diabetes.
  • Genome-wide studies reveal genetic variants affecting circulating protein levels associated with heart disease.
  • Mendelian randomization shows ACE2 has a protective causal effect on systolic blood pressure.

Cite This Study

McGurk et al. (2025) studied this question.

synapsesocial.com/papers/68e6a0f4718ef0a556b3404ahttps://doi.org/10.1161/circgen.124.005005
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