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December 19, 2025Open Access

Proteomic analysis identifies lipoprotein(a)-associated proteins linked to incident atherosclerotic cardiovascular disease events

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Authors

TBTiffany R. BellomoSSSeyedmohammad SaadatagahJLJiwoo Lee

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Overview

Proteomic analysis identifies lipid-associated proteins impacting incident ASCVD and coronary artery disease, suggesting new potential targets.

Key Points

  • The study aimed to identify plasma proteins associated with lipoprotein(a) and their relation to atherosclerotic cardiovascular disease.
  • Analyzed data from 48,859 UK Biobank participants and 9,416 ARIC study participants.
  • Used linear models to assess associations between lipoprotein(a) and protein concentrations, adjusting for several health factors.
  • Replicated results in ARIC participants using a different proteomic platform.
  • Conducted Cox proportional hazards models to quantify protein associations with incident ASCVD.
  • Identified 164 proteins significantly associated with lipoprotein(a) after correction.
  • Five proteins showed concordant associations with lipoprotein(a) and incident ASCVD.
  • ITIH3 associated positively with multiple cardiovascular events, including coronary artery disease and ischemic stroke.
  • CBLN4 inversely associated with higher lipoprotein(a) levels suggesting a protective effect against coronary artery disease.

Cite This Study

Bellomo et al. (2025) studied this question.

synapsesocial.com/papers/69449a892f0218eca95083fdhttps://doi.org/10.64898/2025.12.16.25342337
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