Proteome wide association study uncovers potential treatment targets for cardiovascular diseases, highlighting causal proteins.
Key Points
Identified 72 proteins causally linked to cardiovascular diseases, offering new treatment targets.
From a cohort of 53,022 individuals, 155 proteins were associated with cardiovascular diseases, with 72 showing causal relationships.
Using the Functional Summary-based Imputation framework, the study integrated SNP-protein weights with GWAS data from over 1.3 million subjects.
Promising diagnostic models were built, achieving areas under the curve exceeding 0.8 for 14 of 18 diseases, indicating significant diagnostic potential.