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September 10, 2025African Journal of Reproductive Health

Expression of homeobox B13 gene and metabolomics study in placental tissues of gestational diabetes mellitus

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Authors

LGLijuan GuoDXDan XuJZJianbo Zhou

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Overview

Observational analysis identified lower HOXB13 expression in placental tissues of gestational diabetes mellitus, suggesting metabolic dysregulation.

Key Points

  • HOXB13 expression is significantly lower in placentas from gestational diabetes mellitus compared to normal pregnancies.
  • A total of 337 differential metabolites were identified, with a notable proportion being lipids and lipid-like molecules.
  • Metabolomics analysis revealed reduced glucose and galactose levels in the placentas of the gestational diabetes group.
  • Pathway analysis shows these differential metabolites are enriched in steroid hormone biosynthesis and lipid metabolism pathways.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68c2443bb210217d647aa1c1https://doi.org/10.29063/ajrh2025/v29i8.13
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HOXA13 promotes high glucose-induced trophoblast cell growth and migration during gestational diabetes by regulating the smad2 pathway2025
  2. 2Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus2025
  3. 3Effects of Gestational Metabolic Abnormalities on Placenta2025
  4. 4Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes2025
  5. 5Comprehensive Genetic and Pathway Analysis of Gestational Diabetes: A Multidimensional Bioinformatics Approach2025