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October 15, 2025Biosciences Biotechnology Research AsiaOpen Access

Comprehensive Genetic and Pathway Analysis of Gestational Diabetes: A Multidimensional Bioinformatics Approach

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Authors

UAUsha AdigaSVSampara VasishtaPPPeddareddemma Petlu

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Overview

Bioinformatics approach uncovers metabolic and inflammatory pathways in gestational diabetes, suggesting new therapeutic targets.

Key Points

  • Strong enrichment in vitamin B12 and folate metabolism pathways highlights nutritional-genetic interactions.
  • Key genes like IL6, INSR, LEP, TNF, and CRP indicate roles in metabolic and inflammatory regulation.
  • Analysis revealed pathways related to adipogenesis and leptin-insulin signaling as central to disease mechanisms.
  • Identification of potential therapeutic agents such as statins and anti-inflammatory drugs paves the way for targeted treatments.

Cite This Study

Adiga et al. (2025) studied this question.

synapsesocial.com/papers/68efd921056559ef42877596https://doi.org/10.13005/bbra/3421
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1ACOG Practice Bulletin No. 190: Gestational Diabetes Mellitus2018 · 1,846 citations