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September 5, 2025HereditasOpen Access

HOXA13 promotes high glucose-induced trophoblast cell growth and migration during gestational diabetes by regulating the smad2 pathway

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Authors

FZFei ZhaoXLXinhong LiuQHQin Hong

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Overview

Experimental analysis demonstrates HOXA13's role in promoting cell proliferation and migration in gestational diabetes, indicating its potential as a therapeutic target.

Key Points

  • HOXA13 significantly accelerates trophoblast cell growth and migration under high glucose conditions.
  • In GDM patients, HOXA13 was found to be lowly expressed in placental tissues, while its overexpression counteracted negative effects of glucose.
  • Analysis involved GDM cell and rat models, employing assays for cell proliferation and migration alongside genetic expression measurements.
  • These findings suggest that targeting HOXA13 could improve management and outcomes in gestational diabetes.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64778efbhttps://doi.org/10.1186/s41065-025-00542-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of homeobox B13 gene and metabolomics study in placental tissues of gestational diabetes mellitus2025
  2. 2Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus2025
  3. 3Comprehensive Genetic and Pathway Analysis of Gestational Diabetes: A Multidimensional Bioinformatics Approach2025
  4. 4Expression of Angiogenic and Endothelial Dysfunction Genes in Gestational Diabetes Mellitus: Focus on VEGF-A and ALOX122025
  5. 5Effects of Gestational Metabolic Abnormalities on Placenta2025