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July 22, 2025

Dysregulation of placental mitochondrial structure dynamics and clearance in maternal obesity and gestational diabetes

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Authors

LKLeena KadamKCKaylee ChanETEthan Tawater

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Overview

Research reveals distinct effects of obesity and gestational diabetes on placental mitochondria, suggesting complex sex-specific mechanisms.

Key Points

  • Maternal obesity and gestational diabetes disrupt placental mitochondria, affecting energy production.
  • Significant changes in mitochondrial protein expression were found in placentas of obese women compared to lean.
  • Fetal sex influenced mitochondrial structure dynamics, with notable declines in fission in OB and GDM placentas.
  • Obesity partially activates mitophagy pathways, but GDM placentas do not show similar responses, indicating impaired function.

Cite This Study

Kadam et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd7d3https://doi.org/10.1101/2025.07.17.665416
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity concurrent with gestational diabetes mellitus dysregulates mitochondria-endoplasmic reticulum contacts in human placenta2025
  2. 2Effects of Gestational Metabolic Abnormalities on Placenta2025
  3. 3Placental dysfunction in maternal obesity is a key mechanism of fetal programming of metabolic syndrome2025
  4. 4Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus2025
  5. 5Placental Mitochondrial Calcium Uniporter Modulates Offspring Susceptibility to Metabolic Dysfunction2025