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October 2, 2025International Journal of Molecular SciencesOpen Access

Gene Expression Profile of Placenta and Adipose Tissue in Women with Gestational Diabetes Mellitus

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Authors

RSRenata SaucedoEMErika Magallón-GayónRCRocío Alejandra Chávez-Santoscoy

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Overview

Analysis reveals altered gene expression in placenta and adipose tissue of women with gestational diabetes mellitus, indicating critical molecular pathways involved.

Key Points

  • A total of 179 differentially expressed genes were identified in the placenta, indicating substantial changes in gene expression.
  • RNA sequencing revealed significant alterations in gene pathways related to metabolism and signaling in gestational diabetes mellitus.
  • Differential expression analysis showed upregulated genes involved in G-protein-coupled receptor signaling and downregulated genes linked to cell motility.
  • This work highlights the potential involvement of disordered molecular pathways in the pathogenesis of gestational diabetes mellitus.

Cite This Study

Saucedo et al. (2025) studied this question.

synapsesocial.com/papers/68de68e583cbc991d0a20ed7https://doi.org/10.3390/ijms26199595
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of homeobox B13 gene and metabolomics study in placental tissues of gestational diabetes mellitus2025
  2. 2Microarray Analysis of Differentially Expressed Genes in Peripheral Blood of Postpartum Women with Gestational Diabetes Mellitus and Type 2 Diabetes2025
  3. 3Upregulation of Placental Vitamin D Receptor Expression in Gestational Diabetes Is Not Directly Related to Vitamin D Concentration2025
  4. 4Comprehensive Genetic and Pathway Analysis of Gestational Diabetes: A Multidimensional Bioinformatics Approach2025
  5. 5Effects of Gestational Metabolic Abnormalities on Placenta2025