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September 10, 2025Pediatric Hematology and Oncology

Infectious Complications During Reinduction in Children with Relapsed Acute Lymphoblastic Leukemia: A Descriptive Analysis

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Authors

RCRozalyn ChokALAmanda M. Li

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Overview

Descriptive analysis reveals significant infection rates during chemotherapy reinduction in children with relapsed ALL, suggesting urgent need for improved strategies.

Key Points

  • About half of the patients experienced at least one infection, with 16% affected by confirmed or probable fungal infection.
  • Infection was linked to longer hospitalization, with a median of 17 days compared to 7 days without infection.
  • The retrospective analysis included 43 children, all treated with combination chemotherapy for relapsed acute lymphoblastic leukemia.
  • Infection risks are notable during reinduction chemotherapy, highlighting the need for safer treatment methods.

Cite This Study

Chok et al. (2025) studied this question.

synapsesocial.com/papers/68c2443bb210217d647a9f51https://doi.org/10.1080/08880018.2025.2550516
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real World Incidence and Etiology of Infectious Complications in Adults With Ph‐Negative Acute Lymphoblastic Leukemia Treated With the Pediatric‐Inspired GIMEMA LAL1913 Program. A Campus All Study2025
  2. 2Induction mortality in acute leukemia: The hidden burden of infections in a middle-income country2025
  3. 3Treatment-Related Toxicity Profile in Children with Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma during Induction Chemotherapy: Prospective Insights from a South Indian Cohort2025
  4. 4Prognostic factors influencing relapse and survival of childhood acute lymphoblastic leukemia with the ALL-BFM IC 2009 protocol2025
  5. 5Cytopenias and infectious complications following CD19-directed CAR-T cell therapy in patients with B-ALL: A single-center retrospective analysis2025