Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Induction mortality in acute leukemia: The hidden burden of infections in a middle-income country

View Full Paper
Ask AI
Bookmark
Share

Authors

AMAnaly Mora

Discussion

Loading...

Member takes

Overview

Retrospective cohort study estimates induction-related mortality in adults with acute leukemia, suggesting improved antimicrobial prophylaxis is crucial.

Key Points

  • Induction-related mortality remains high at 10.4%, with infections causing 74.3% of deaths.
  • Age ≥45 years and mechanical ventilation significantly linked to induction mortality, indicating risk factors.
  • Observational cohort study analyzed trends in infectious complications and supportive care practices from 2005 to 2022.
  • Antimicrobial prophylaxis improvements underscore urgent need for tailored national guidelines to optimize care.

Cite This Study

Analy Mora (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236de5chttps://doi.org/10.1182/blood-2025-1545
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Determinants of early mortality following induction chemotherapy in Acute Myeloid Leukemia: Experience from a comprehensive cancer center in Latin America2025
  2. 2Hematologic predictors of serious infection and impact of serious infection on long-term mortality in AML patients: Insights from propensity-matched real-world cohorts2025
  3. 3Trends in sepsis-related mortality among patients with Acute Myeloid Leukemia: A 24-year nationwide analysis2025
  4. 4Infectious Complications During Reinduction in Children with Relapsed Acute Lymphoblastic Leukemia: A Descriptive Analysis2025
  5. 5Treatment-Related Mortality in Pediatric Acute-Lymphoblastic and Myeloid Leukemia: Experience from A Low- and Middle-Income Setting2025