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December 8, 2025BloodOpen Access

Prognostic factors influencing relapse and survival of childhood acute lymphoblastic leukemia with the ALL-BFM IC 2009 protocol

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Retrospective analysis finds higher relapse rates in children with elevated WBC, suggesting critical prognostic factors.

Children with acute lymphoblastic leukemia show a 5-year overall survival rate of 88.3% and event free survival of 84.4%.
Elevated white blood cell count at diagnosis predicted worse outcomes, with hazard ratio 2.76 for mortality.
Logistic regression identified age ≥6 years and WBC >100,000/mm³ as key independent predictors of relapse.
Survival analysis indicates that all deaths occurred in patients who relapsed, highlighting the severity of early mortality.

Tekin Aksu (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Retrospective analysis finds higher relapse rates in children with elevated WBC, suggesting critical prognostic factors.

Children with acute lymphoblastic leukemia show a 5-year overall survival rate of 88.3% and event free survival of 84.4%.
Elevated white blood cell count at diagnosis predicted worse outcomes, with hazard ratio 2.76 for mortality.
Logistic regression identified age ≥6 years and WBC >100,000/mm³ as key independent predictors of relapse.
Survival analysis indicates that all deaths occurred in patients who relapsed, highlighting the severity of early mortality.

Tekin Aksu (2025) studied this question.

View Full Paper

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