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August 26, 2025Indian Journal of Medical and Paediatric OncologyOpen Access

Treatment-Related Toxicity Profile in Children with Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma during Induction Chemotherapy: Prospective Insights from a South Indian Cohort

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Authors

MSMonica SelvanJRJaikumar Govindaswamy Ramamoorthy

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Overview

Prospective cohort study found high treatment-related toxicity and mortality in children with ALL, highlighting critical management needs.

Key Points

  • A total of 696 toxicities were recorded among 101 children, indicating high treatment-related toxicity rates in the cohort.
  • Hematological toxicities were prominent, with 73.2% occurring at grade 3 and above, suggesting serious health impacts.
  • The prospective cohort study involved children aged 1 month to 15 years undergoing induction chemotherapy, providing vital insights into care needs.
  • The study reflects significant mortality concerns with an 8.9% induction mortality rate, mainly driven by infection-related factors.

Cite This Study

Selvan et al. (2025) studied this question.

synapsesocial.com/papers/68af7dec7567bf4f94ff47e6https://doi.org/10.1055/s-0045-1811561
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