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August 12, 2025Hematological OncologyOpen Access

Real World Incidence and Etiology of Infectious Complications in Adults With Ph‐Negative Acute Lymphoblastic Leukemia Treated With the Pediatric‐Inspired GIMEMA LAL1913 Program. A Campus All Study

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Authors

PZPatrizia ZappasodiLCLudovica CalabrettaVFVirginia Valeria Ferretti

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Overview

Analysis of infection rates in 240 adults with Ph-negative acute lymphoblastic leukemia, highlighting risk factors and outcomes.

Key Points

  • Around 60% of patients with adult Ph-negative ALL experienced an infectious episode, with bacterial infections being the most frequent.
  • Of 240 patients, 145 had an infection, and invasive fungal infections occurred in 12.5% during treatment with GIMEMA LAL1913.
  • Observational analysis of infections in newly diagnosed adult Ph-negative ALL patients treated across 18 centers.
  • Older age, particularly over 65, is a significant risk factor for infections, underscoring the need for better prophylaxis.

Cite This Study

Zappasodi et al. (2025) studied this question.

synapsesocial.com/papers/68a34d6a234c60ad5c20a607https://doi.org/10.1002/hon.70121
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