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September 10, 2025Open Access

Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex

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Authors

JZJing ZhangDZDan ZhouWZWenli Zhai

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Overview

Comprehensive analysis reveals epigenetic changes in the prefrontal cortex, connecting aging and Alzheimer's disease, suggesting crucial biological implications.

Key Points

  • Significant age-associated DNA methylation changes in the prefrontal cortex uncover critical epigenetic links to Alzheimer's disease.
  • Over one-third of tested CpG sites showed methylation changes, with 485 sites linked to Alzheimer's neuropathologic change.
  • Mediation analysis indicates that DNA methylation mediates 27.3% of aging's impact on Alzheimer's neuropathology.
  • Findings highlight the importance of examining diverse populations, as marked differences between East Asian and European methylation profiles were observed.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c243f6b210217d647a8fcehttps://doi.org/10.21203/rs.3.rs-7381745/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer's Disease2025
  2. 2DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 3 citations
  3. 3DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 12 citations
  4. 4Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer's Disease.2025
  5. 5Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology2025