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August 1, 2025Open Access

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology

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Authors

SLSzi Kay LeungEWEmma WalkerSPStefania Policicchio

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Overview

Analysis reveals alterations in dna methylation related to tau and amyloid-β in transgenic mouse models of alzheimer's disease, suggesting new therapeutic targets.

Key Points

  • Core finding demonstrates distinct dna methylation patterns associated with tau and amyloid-β pathology in transgenic mouse models.
  • Evidence shows extensive alterations in dna methylation linked to tau accumulation in rTg4510 mice, affecting genes related to neuronal functions.
  • Methodology included reduced representation bisulfite sequencing and methylation arrays to profile dna methylation changes across disease stages.
  • Significance lies in identifying early epigenetic alterations that may inform potential interventions for alzheimer's disease.

Cite This Study

Leung et al. (2025) studied this question.

synapsesocial.com/papers/689a0c65e6551bb0af8cf8e8https://doi.org/10.1101/2025.07.28.666515
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Also Consider

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  1. 1Epigenetic Shifts Reveal Alzheimer’s Origins after Sustained Picomolar Aβ Exposure2025
  2. 2Microglial transcriptional profiles of a transgenic rat model closely model Alzheimer's disease2026
  3. 3Predictive gene expression signatures for Alzheimer’s disease using post-mortem brain tissue2025
  4. 4Brain Region-Specific Epigenomic Reorganization and Altered Cell States in Alzheimer's Disease2025
  5. 5Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer's Disease.2025