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July 25, 2025Open Access

DNA Methylation Ageing Atlas Across 17 Human Tissues

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Authors

MJMacsue JacquesKSKirsten SealeSVSarah Voisin

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Overview

Meta-analysis reveals distinct aging methylation patterns in 17 tissues, suggesting new biomarkers and therapeutic targets.

Key Points

  • Main finding reveals both conserved and tissue-specific aging signatures within human dna methylation patterns.
  • Key evidence includes analysis of over 15,000 human methylomes across 17 tissues showing aging signals.
  • Approach involved examining changes in differentially and variably methylated positions to assess aging impact.
  • Significance lies in providing an open-access atlas useful for identifying biomarkers and advancing epigenetic therapies.

Cite This Study

Jacques et al. (2025) studied this question.

synapsesocial.com/papers/689a0627e6551bb0af8ce01fhttps://doi.org/10.1101/2025.07.21.665830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 3 citations
  2. 2Epigenetic signature of heterogeneity in aging: Findings from the Canadian Longitudinal Study on Aging2025
  3. 3Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex2025
  4. 4DNMT1-mediated epigenetic regulation of heterochromatin in cellular aging2025
  5. 5DNA methylation landscapes in human cells and their chromatin determinants2025