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August 16, 2025Open Access

DNA Methylation Ageing Atlas Across 17 Human Tissues

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Authors

NENir EynonMJMacsue JacquesKSKirsten Seale

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Overview

Meta-analysis identifies conserved and tissue-specific aging signatures in over 15,000 human methylomes, suggesting new therapeutic targets.

Key Points

  • The study reveals comprehensive changes in dna methylation linked to aging across multiple tissues, indicating potential intervention points.
  • Notable findings indicate that certain genes, including PCDHGA1 and HOX, worsen aging signals, suggesting their role in tissue health.
  • Using large-scale meta-analysis of methylomes, researchers identified both conserved and unique aging signatures tied to specific tissues.
  • The findings underline the importance of epigenetic changes in aging, supporting further exploration of biomarkers for therapeutic strategies.

Cite This Study

Eynon et al. (2025) studied this question.

synapsesocial.com/papers/68c235fdb210217d6477300fhttps://doi.org/10.21203/rs.3.rs-7184037/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DNA Methylation Ageing Atlas Across 17 Human Tissues2025 · 12 citations
  2. 2Epigenetic Rewiring Connects Aging to Alzheimer’s Pathology in the Human Prefrontal Cortex2025
  3. 3DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging2025
  4. 4DNMT1-mediated epigenetic regulation of heterochromatin in cellular aging2025
  5. 5Epigenetic markers of middle-age: non-linear DNA methylation changes with aging in humans2025 · 1 citations