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August 13, 2025

Epigenomic Aberrations of Histone Methylation in Prefrontal Cortex of Humans with Mild Cognitive Impairment and Alzheimer's Disease.

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Authors

PPPrachetas J. PatelZYZhen Yan

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Overview

Observational analysis reveals altered histone methylation in the prefrontal cortex of MCI and AD patients, indicating potential therapeutic targets.

Key Points

  • Significant losses of permissive H3K4me3 peaks were found in MCI and AD compared to controls, affecting key synaptic genes.
  • Mild cognitive impairment showed more pronounced gains of repressive H3K27me3 peaks than Alzheimer's, driving gene dysregulation.
  • Weighted Gene Correlation Network Analysis identified distinct patterns of histone mark alterations from MCI to AD.
  • Targeting these epigenomic changes could provide new strategies for early intervention in Alzheimer's disease.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d647716f3https://doi.org/10.1101/2025.07.17.25331659
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