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September 10, 2025Lipids in Health and DiseaseOpen Access

Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese

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Authors

SWShouxin WeiSYSijia YuCQChuan Qian

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Overview

Retrospective analysis highlights eGDR's role in reducing hyperlipidemia and mortality risk, indicating clinical relevance.

Key Points

  • Each standard deviation increase in eGDR resulted in an 11.5% reduction in hyperlipidemia risk in the NHANES cohort, signifying its predictive power.
  • The analysis revealed an 8.6% reduction in all-cause mortality (HR = 0.914) with higher eGDR levels, showcasing its potential as a health marker.
  • Cox models and logistic regression were employed to analyze mortality and hyperlipidemia risk, supporting eGDR’s clinical utility in metabolic disease.
  • Findings suggest that enhancing eGDR can alleviate the health burden tied to hyperlipidemia and indicate a need for its integration in clinical assessments.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a588ahttps://doi.org/10.1186/s12944-025-02684-6
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Also Consider

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  1. 1The association between insulin resistance assessed by estimated glucose disposal rate and stroke prevalence and mortality in non-diabetic people: evidence from two prospective cohorts2025
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  3. 3Insulin resistance assessed by estimated glucose disposal rate is associated with all-cause and cardiovascular mortality among postmenopausal women2025
  4. 4Estimated Glucose Disposal Rate and Mortality in Cardiovascular Kidney Metabolic Syndrome: Nonlinear Associations and Stratified Prognostic Significance by Glycometabolic Phenotypes2025
  5. 5Association between estimated glucose disposal rate and cardiovascular disease prevalence and mortality outcomes in metabolic dysfunction-associated steatotic liver disease: a comparative analysis of insulin resistance markers2025