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August 17, 2025

Estimated Glucose Disposal Rate and Mortality in Cardiovascular Kidney Metabolic Syndrome: Nonlinear Associations and Stratified Prognostic Significance by Glycometabolic Phenotypes

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Authors

ZZZheng ZhangCFChao FuYCYiyi Chai

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Overview

Cohort study demonstrates eGDR's associations with mortality across glycometabolic phenotypes, highlighting its prognostic significance.

Key Points

  • Significant associations were found between eGDR levels and both all-cause and cause-specific mortality.
  • Nonlinear relationships were observed between eGDR and all-cause mortality, indicating a complex interaction in patient prognosis.
  • Cohort study used Cox proportional risk and ROC curve analyses to evaluate mortality risks associated with eGDR levels.
  • Findings suggest eGDR is a strong predictor of mortality risk, potentially guiding treatment strategies for CKM patients.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68a35486234c60ad5c20ebf2https://doi.org/10.21203/rs.3.rs-7258966/v1
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Also Consider

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  1. 1The combined prognostic effect of the triglyceride-glucose index and estimated glucose disposal rate on long-term mortality among individuals with cardiovascular-kidney-metabolic syndrome stages 0–32025
  2. 2Estimated glucose disposal rate and its dual role in hyperlipidemia risk and mortality: a secondary analysis of retrospective cohort data from U.S. and Chinese2025
  3. 3Changes in the Estimated Glucose Disposal Rate and Incident Cardiovascular Disease in Patients with Cardiovascular–Kidney–Metabolic Syndrome Stages 0–3: A Prospective Cohort Study in China2025
  4. 4Changes in the estimated glucose disposal rate and incident cardiovascular disease in patients with cardiovascular–kidney–metabolic syndrome stages 0–3: a prospective cohort study in China2025
  5. 5Associations between estimated glucose disposal rate and age-related ocular diseases in cardiovascular-kidney-metabolic syndrome stages 0–3: a large prospective cohort study2025