Cohort analysis links insulin resistance measured by eGDR to higher all-cause and cardiovascular mortality risks in postmenopausal women.
Key Points
Higher estimated glucose disposal rate (eGDR) correlates with lower all-cause and cardiovascular mortality in postmenopausal women.
The study documented 2151 all-cause deaths and 679 cardiovascular deaths during an average follow-up of 98 months.
Multivariate Cox regression analysis identified a U-shaped relationship between eGDR and all-cause mortality, with an inflection point at 5.11 mg/kg/min.
The strongest association was observed in women under 60, indicating varying impacts of insulin resistance across age groups.