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October 12, 2025Diabetology & Metabolic SyndromeOpen Access

The association between insulin resistance assessed by estimated glucose disposal rate and stroke prevalence and mortality in non-diabetic people: evidence from two prospective cohorts

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Authors

DLDandan LiYGYan GuoFCFang Cui

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Overview

Cross-sectional analysis reveals insulin resistance measures lower stroke prevalence and mortality rates in non-diabetic adults, suggesting potential health benefits.

Key Points

  • Higher eGDR is significantly linked to lower stroke prevalence and reduced mortality in non-diabetic individuals.
  • Data from NHANES showed a significant decrease in stroke prevalence (OR 0.44) and all-cause mortality (HR 0.78) with higher eGDR levels.
  • Multivariate analyses using Cox proportional hazards models identified strong associations between eGDR and stroke outcomes over a median follow-up of 117.6 months.
  • Findings from CHARLS confirm that higher eGDR independently correlates with reduced risk of stroke and mortality among non-diabetic populations.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68ebc91af2c3e4d8d926e225https://doi.org/10.1186/s13098-025-01956-6
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Cohort Profile: The China Health and Retirement Longitudinal Study (CHARLS)2012 · 5,497 citations