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September 10, 2025Cell Communication and SignalingOpen Access

Biomechanics of the tumor extracellular matrix and regulatory T cells: regulatory mechanisms and potential therapeutic targets

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Authors

WHWenbo HuangHLHung‐Wen LaiJLJing Long

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Overview

Review highlights how extracellular matrix stiffness affects regulatory T cells' function, suggesting new cancer immunotherapy targets.

Key Points

  • Increased stiffness of the extracellular matrix enhances differentiation of regulatory T cells in tumors.
  • The structural remodeling of the extracellular matrix significantly boosts Treg migration and immunosuppressive capabilities.
  • Biomechanical signals enable stronger oxidative phosphorylation in Tregs, enhancing their metabolic function.
  • Targeting mechanotransduction pathways in Tregs may provide innovative strategies for cancer treatment.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4bc1https://doi.org/10.1186/s12964-025-02380-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biophysical Properties of the Extracellular Matrix in Cancer: Insights Into Immunotherapy2025
  2. 2Principal mechanisms of extracellular matrix‐mediated cell–cell communication in physiological and tumor microenvironments2025 · 13 citations
  3. 3Glycosylated extracellular matrix drives immune suppression by controlling T cell movement, macrophage phenotype, and macrophage-T cell crosstalk in triple negative breast cancer2025
  4. 4Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets2025
  5. 5The mechanobiology of extracellular matrix: a focus on thrombospondins2025